Projects

EMPLOYING GENOMICS, EPIGENETICS, AND IMMUNOGENETICS TO CONTROL DISEASES INDUCED BY AVIAN TUMOR VIRUSES Appropriated (D)   Accession Number: 423660

THE EPIGENETIC LANDSCAPE FOR MAREK'S DISEASE SUSCEPTIBILITY AND RESISTANCE IN CHICKENS Reimbursable (R)   Accession Number: 418582

GENETIC AND EPIGENETIC RESISTANCE TO MAREK'S DISEASE Specific Cooperative Agreement (S)   Accession Number: 420069

Publications (Clicking on the reprint icon will take you to the publication reprint.)

DNMT gene expression and methylome in Marek’s disease resistant and susceptible chickens prior to and following infection by MDV - (Peer Reviewed Journal)

Tian, F., Zhan, F., Vanderkraats, N.D., Hiken, J.F., Edwards, J.R., Zhang, H., Zhao, K., Song, J. 2012. DNMT gene expression and methylome in Marek’s disease resistant and susceptible chickens prior to and following infection by MDV. Epigenetics. 8(4):431-444.

DNA methylation down-regulates EGFR expression in chicken - (Peer Reviewed Journal)

Luo, J., Chang, S., Zhang, H., Li, B., Song, J. 2013. DNA methylation down-regulates EGFR expression in chicken. Avian Diseases. 57(2):366-371.

Deletion of Marek’s disease virus large subunit of ribonucleotide reductase (RR) impairs virus growth in vitro and in vivo - (Peer Reviewed Journal)

Sun, A., Lee, L.F., Khan, O., Heidari, M., Zhang, H., Lupiani, B., Reddy, S. 2013. Deletion of Marek’s disease virus large subunit of ribonucleotide reductase (RR) impairs virus growth in vitro and in vivo. Avian Diseases. 57(2):464-468.

Identification and in vitro characterization of a Marek’s disease virus encoded ribonucleotide reductase - (Peer Reviewed Journal)

Lee, L.F., Heidari, M., Sun, A., Zhang, H., Lupiani, B., Reddy, S.M. 2013. Identification and in vitro characterization of a Marek’s disease virus encoded ribonucleotide reductase. Avian Diseases. 57:178-187.

Properties of a meq-deleted rMd5 Marek’s disease vaccine: protection against virulent MDV challenge and induction of lymphoid organ atrophy are simultaneously attenuated by serial passage in vitro - (Peer Reviewed Journal)

Lee, L.F., Kreager, K., Heidari, M., Zhang, H., Lupiani, B., Reddy, S.M., Fadly, A.M. 2013. Properties of a meq-deleted rMd5 Marek’s disease vaccine: protection against virulent MDV challenge and induction of lymphoid organ atrophy are simultaneously attenuated by serial passage in vitro. Avian Diseases. 57(2):491-497.

Host Genetics and Vaccine Efficacy: Global gene expression differentiation induced by vaccine and MDV in MD resistant and susceptible chickens based on Next-Gen RNA-Seq reads - (Abstract Only)

Zhang, H., Chang, S., Xie, Q., Song, J., Ernst, C. 2013. Host Genetics and Vaccine Efficacy: Global gene expression differentiation induced by vaccine and MDV in MD resistant and susceptible chickens based on Next-Gen RNA-Seq reads [abstract]. Plant and Animal Genome XXI Conference, January 12-16, 2013, San Diego, California. A-W640. Available: https://pag.confex.com/pag/xxi/webprogram/Paper5459.html.

Identification of specific long noncoding RNA profiles in chicken with different susceptibility to Marek's disease - (Abstract Only)

Luo, J., Zhang, H., Zhao, K., Song, J. 2013. Identification of specific long noncoding RNA profiles in chicken with different susceptibility to Marek's disease [abstract]. Plant and Animal Genome XXI Conference, January 12-16, San Diego, California. A-P0651. Available:https://pag.confex.com/pag/xxi/webprogram/Paper5186.html.

Marek's Disease Virus Infection Induces Widespread Differential Chromatin Marks in Inbred Chicken Lines - (Abstract Only)

Mitra, A., Luo, J., Zhang, H., Zhao, K., Song, J. 2013. Marek's Disease Virus Infection Induces Widespread Differential Chromatin Marks in Inbred Chicken Lines [abstract]. Plant and Animal Genome XXI Conference, January 12-16, 2013, San Diego, California. A-P0650. Available:https://pag.confex.com/pag/xxi/webprogram/Paper5688.html.

Genome-wide copy number variant analysis in inbred chickens lines with different susceptibility to Marek's disease - (Abstract Only)

Luo, J., Yu, Y., Mitra, A., Zhang, H., Liu, G., Song, J. 2013. Genome-wide copy number variant analysis in inbred chickens lines with different susceptibility to Marek's disease [abstract]. Plant and Animal Genome XXI Conference, January 12-16, 2013, San Diego, California. A-P0649. Avaliable: https://pag.confex.com/pag/xxi/webprogram/Paper5185.html.

Genome-wide copy number variant analysis in inbred chicken lines with different susceptibility to Marek’s disease - (Peer Reviewed Journal)

Luo, J., Yu, Y., Mitra, A., Chang, S., Zhang, H., Liu, G., Yang, N., Song, J. 2013. Genome-wide copy number variant analysis in inbred chicken lines with different susceptibility to Marek’s disease. Genes, Genomes, and Genomics. 3:217-223. Available: http://www.g3journal.org/lookup/suppl/doi:10.1534/g3.112.005132/-/DC1.

Marek’s disease virus infection induces widespread differential chromatin marks in inbred chicken lines - (Peer Reviewed Journal)

Mitra, A., Luo, J., Zhang, H., Cui, K., Zhao, K., Song, J. 2012. Marek’s disease virus infection induces widespread differential chromatin marks in inbred chicken lines. Biomed Central (BMC) Genomics. 2012(13):557. available: http://www.biomedcentral.com/1471-2164/13/557.

Host genetic variation is a contributable factor for imperfectly-immunizing vaccination - (Abstract Only)

Zhang, H. 2012. Host genetic variation is a contributable factor for imperfectly-immunizing vaccination. Meeting Abstract. RAPIDD Imprefectly Immunizing Vaccine Workshop, August 15-17, 2012, Dearborn, MI.

Complete genome sequence of an avian leukosis virus isolate associated with hemangioma and myeloid leukosis in egg-type and meat-type chickens - (Peer Reviewed Journal)

Ji, J., Li, H., Zhang, H., Xie, Q., Shang, H., Ma, J., Bi, Y. 2012. Complete genome sequence of an avian leukosis virus isolate associated with hemangioma and myeloid leukosis in egg-type and meat-type chickens. Journal of Virology. 86(19):10907-10908.

Aberrant expression of liver microRNA in chickens infected with subgroup J avian leukosis virus - (Peer Reviewed Journal)

Li, H., Yji, J., Xie, Q., Shang, H., Zhang, H., Xin, X., Chen, F., Sun, B. 2012. Aberrant expression of liver microRNA in chickens infected with subgroup J avian leukosis virus. Virus Research. 169(2012):268-271. Available: http://dx.doi.org/10.1016/j.virusres.2012.07.003.

Histone methylation analysis and pathway predictions in chickens after MDV infection - (Peer Reviewed Journal)

Luo, J., Mitra, A., Tian, F., Chang, S., Zhang, H., Cui, K., Yu, Y., Zhao, K., Song, J. 2012. Histone methylation analysis and pathway predictions in chickens after MDV infection. PLoS One. 7(7). Available: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0041849.

Complete genome sequence of a novel H9N2 subtype influenza virus FJG9 strain in china reveals a natural reassortant event - (Research Notes)

Xie, Q., Yan, Z., Ji, J., Zhang, H., Liu, J., Sun, Y., Li, Q., Chen, F. 2012. Complete genome sequence of a novel H9N2 subtype influenza virus FJG9 strain in china reveals a natural reassortant event. Journal of Virology. 86(18):10240-10241.

DNA methylation down-regulates EGFR expression in chicken - (Abstract Only)

Luo, J., Chang, S., Zhang, H., Song, J. 2012. DNA methylation down-regulates EGFR expression in chicken [Abstract]. 9th International Symposium on Marek's Disease and Avian Herpesviruses, June 24-28, 2012, Freie Universitat Berlin. p. 23.

Pathogenesis and protective efficacy of attenuated Meq null rMd5 virus in maternal antibody negative and commercial chickens. - (Abstract Only)

Lee, L.F., Kreager, K.S., Heidari, M., Zhang, H., Lupiani, B., Reddy, S.M., Fadly, A.M. 2012. Pathogenesis and protective efficacy of attenuated Meq null rMd5 virus in maternal antibody negative and commercial chickens [abstract]. 9th International Symposium on Marek's Disease and Avian Herpesviruses, June 24-28, 2012, Freie Universitat Berlin. p. 42.

Marek’s disease virus encoded ribonucleotide reductase large subunit is essential for in vivo replication and plays a critical role in viral pathogenesis. - (Abstract Only)

Sun, A., Lee, L.F., Heidari, M., Zhang, H., Lupiani, B., Reddy, S.M. 2012. Marek’s disease virus encoded ribonucleotide reductase large subunit is essential for in vivo replication and plays a critical role in viral pathogenesis [abstract]. 9th International Symposium on Marek's Disease and Avian Herpesviruses, June 24-28, 2012, Freie Universitat Berlin. p. 60.

Differential genetic variation of chickens and MD vaccine protective efficacy - (Abstract Only)

Xie, Q., Chang, S., Ernst, C.W., Dunn, J.R., Song, J., Zhang, H. 2012. Differential genetic variation of chickens and MD vaccine protective efficacy [abstract]. 9th International Symposium on Marek's Disease and Avian Herpesviruses, June 24-28, 2012, Freie Universitat Berlin. p.36.

Quantitation of Marek’s disease virus in vaccinated population of resistant and susceptible chicken samples using real-time PCR - (Abstract Only)

Chang, S., Xie, Q., Zhang, H. 2012. Quantitation of Marek’s disease virus in vaccinated population of resistant and susceptible chicken samples using real-time PCR. Meeting Abstract. Poultry Science Association Annual Meeting, July 9-12, 2012, Athens Georgia.

Development of SNP assays to determine genetic resistance to ALV-A in chickens - (Abstract Only)

Xie, Q., Chang, S., Zhang, H. 2012. Development of SNP assays to determine genetic resistance to ALV-A in chickens. Meeting abstract. Poultry Science Association Annual Meeting, July 9-12, 2012, Athens Georgia.

Cell culture attenuation eliminates rMd5deltaMeq-induced bursal and thymic atrophy and renders the mutant virus as an effective and safe vaccine against Marek's disease - (Peer Reviewed Journal)

Lee, L.F., Heidari, M., Zhang, H., Lupiani, B., Reddy, S.M., Fadly, A.M. 2012. Cell culture attenuation eliminates rMd5deltaMeq-induced bursal and thymic atrophy and renders the mutant virus as an effective and safe vaccine against Marek's disease. Vaccine. 30(34):5151-5158.

Comparative study of lipoprotein metabolism differs between Marek's disease susceptible and resistant chickens - (Peer Reviewed Journal)

Yuan, P., Yu, Y., Luo, J., Tian, F., Zhang, H., Chang, S., Ramachandran, R., Song, J. 2012. Comparative study of lipoprotein metabolism in Marek's disease susceptible and resistant chickens. Poultry Science. 91:2598-2605. Available: http://ps.fass.org/content/91/10/2598.

Marek's disease virus challenge induced immune-related gene expression and chicken repeat 1 (CR1) methylation alterations in chickens - (Peer Reviewed Journal)

Fei, T., Luo, J., Zhang, H., Chang, S., Song, J. 2012. Marek's disease virus challenge induced immune-related gene expression and chicken repeat 1 (CR1) methylation alterations in chickens. American Journal of Molecular Biology (AJMB). 2(2012):232-241. Available: http://www.scirp.org/journal/PaperInformation.aspx?paperID=20985.

The chicken frizzle feather is due to an a-keratin (KRT75) mutation that causes a defective rachis - (Peer Reviewed Journal)

Ng, C., Wu, P., Foley, J., Foley, A., McDonald, M., Juan, W., Huang, C., Lai, Y., Lo, W., Chen, C., Leal, S.M., Zhang, H., Widelitz, R.B., Patel, P.I., Li, W., Chuong, C. 2012. The chicken frizzle feather is due to an a-keratin (KRT75) mutation that causes a defective rachis. PLoS Genetics. 8(7). Available: http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1002748.

Very virulent plus strains of MDV induce acute form of transient paralysis in both susceptible and resistant chicken lines - (Peer Reviewed Journal)

Xu, M., Fitzgerald, S.D., Zhang, H., Karcher, D.M., Heidari, M. 2012. Very virulent plus strains of MDV induce acute form of transient paralysis in both susceptible and resistant chicken lines. Viral Immunology. 25(4):306-323.

DNA methylation fluctuation induced by virus infection differs between MD-resistant and -susceptible chickens - (Peer Reviewed Journal)

Luo, J., Yu, Y., Chang, S., Tian, F., Zhang, H., Song, J. 2012. DNA methylation fluctuation induced by virus infection differs between MD-resistant and -susceptible chickens. Frontiers in Genetics. 3(20):1-15. Available: http://www.frontiersin.org/epigenomics/10.3389/fgene.2012.00020/full.

Marek's disease virus infection induces differential chromatin marks and tissue-specific effects in inbred lines of chickens - (Abstract Only)

Mitra, A., Zhang, H., Luo, J., Zhao, K., Song, J. 2012. Marek's disease virus infection induces differential chromatin marks and tissue-specific effects in inbred lines of chickens. Plant and Animal Genome Conference. Available: https://pag.confex.com/pag/xx/webprogram/Paper3259.html.

Host genetic resistance sustains HVT protective efficacy comparable to CV1988/Rispens' in lines of chickens relatively resistant to Marek's disease - (Abstract Only)

Zhang, H., Chang, S., Dunn, J.R., Heidari, M., Song, J., Fulton, J. 2012. Host genetic resistance sustains HVT protective efficacy comparable to CV1988/Rispens' in lines of chickens relatively resistant to Marek's disease. Plant and Animal Genome Conference. Available: https://pag.confex.com/pag/xx/webprogram/Paper3980.html.

Histone methylation analysis and pathway predictions in chickens after MDV infection - (Abstract Only)

Luo, J., Zhang, H., Mitra, A., Zhao, K., Song, J. 2012. Histone methylation analysis and pathway predictions in chickens after MDV infection. Plant and Animal Genome Conference. Available: https://pag.confex.com/pag/xx/webprogram/Paper3632.html.

MiRNA expression signatures induced by Marek disease virus infection in chickens - (Peer Reviewed Journal)

Tian, F., Luo, J., Zhang, H., Chang, S., Song, J. 2012. MiRNA expression signatures induced by Marek disease virus infection in chickens. Genomics. 99(3):152-159. Available: http://www.sciencedirect.com/science/article/pii/S0888754311002618.

Vaccine by chicken line interaction alters the protective efficacy against challenge with a very virulent plus strain of Marek's disease virus in white leghorn chickens - (Peer Reviewed Journal)

Chang, S., Dunn, J.R., Heidari, M., Lee, L.F., Ernst, C.W., Song, J., Zhang, H. 2012. Vaccine by chicken line interaction alters the protective efficacy against challenge with a very virulent plus strain of Marek's disease virus in white leghorn chickens. World Journal of Vaccines. 2(1):1-11. Available: http://www.scirp.org/journal/wjv/.

Temporal transcriptome changes induced by MDV in Marek's disease-resistant and -susceptible inbred chickens - (Peer Reviewed Journal)

Yu, Y., Luo, J., Mitra, A., Chang, S., Tian, F., Zhang, H., Yuan, P., Zhou, H., Song, J. 2012. Temporal transcriptome changes induced by MDV in Marek's disease-resistant and -susceptible inbred chickens. Biomed Central (BMC) Genomics. 12:501. Available: http://www.biomedcentral.com/1471-2164/12/501.

Research update: Avian Disease and Oncology Laboratory avian tumor viruses - (Proceedings)

Fadly, A.M., Cheng, H.H., Dunn, J.R., Heidari, M., Hunt, H.D., Lee, L.F., Silva, R.F., Zhang, H. 2012. Research update: Avian Disease and Oncology Laboratory avian tumor viruses. In: Proceedings for the 115th Annual Meeting of the United States Animal Health Association, September 29-October 5, 2011, Buffalo, New York. 462-464.

Attenuation of Marek's disease virus lacking the Meq oncogene in cell culture - (Abstract Only)

Lee, L.F., Heidari, M., Zhang, H., Reddy, S.M. 2011. Attenuation of Marek's disease virus lacking the Meq oncogene in cell culture [CD-ROM]. American Veterinary Medical Association (AVMA) Convention, July 16-19, 2011, St. Louis, Missouri. Paper No. 11067.

A comparative evaluation of the protective efficacy of rMd5-delta-Meq and CV1988/Rispens against a vv+ strain of Marek's disease virus infection in a series of recombinant congenic strains of white leghorn chickens - (Peer Reviewed Journal)

Chang, S., Ding, Z., Dunn, J.R., Lee, L.F., Heidari, M., Song, J., Ernst, C.W., Zhang, H. 2011. A comparative evaluation of the protective efficacy of rMd5-delta-Meq and CV1988/Rispens against a vv+ strain of Marek's disease virus infection in a series of recombinant congenic strains of white leghorn chickens. Avian Diseases. 55(3):384-390.

Gene Expression Profiling in rMd5- and rMd5-delta-meq-Infected Chickens - (Peer Reviewed Journal)

Xu, M., Zhang, H., Lee, L.F., Gao, H., Sharif, S., Silva, R.F., Heidari, M. 2011. Gene expression profiling in rMd5- and rMd5-delta-meq-infected chickens. Avian Diseases. 55(3):358-367.

The protective efficacy of rMd5deltaMeq against challenge with a very virulent plus strain of MDV in relatively resistant lines of chickens - (Abstract Only)

Chang, S., Dunn, J.R., Lee, L.F., Heidari, M., Song, J.Z., Ernst, C.W., Zhang, H.M. 2011. The protective efficacy of rMd5deltaMeq against challenge with a very virulent plus strain of MDV in relatively resistant lines of chickens [abstract]. Poultry Science Association/American Association of Avian Pathologists Abstracts, July 16-19, 2011, St. Louis, Missouri. p. 124.

Identifying genetic determinants of host resistance to Marek's disease - (Abstract Only)

Zhang, H., Chang, S., Dunn, J.R., Luo, J., Song, J. 2011. Identifying genetic determinants of host resistance to Marek's disease [abstract]. International Plant and Animal Genome Conference PAG XIX, January 15-19, 2011, San Diego, California. Paper #W466. Available: http://www.intl-pag.org/.

Evaluation of Factors Affecting Vaccine Efficacy of Recombinant Marek's Disease Virus Lacking the Meq Oncogene in Chickens - (Peer Reviewed Journal)

Lee, L.F., Zhang, H., Heidari, M., Lupiani, B., Reddy, S. 2011. Evaluation of factors affecting vaccine efficacy of recombinant Marek's disease virus lacking the Meq oncogene in chickens. Avian Diseases. 55(2):172-179.

Genome-wide histone modification profile induced by MDV in MD-resistant and -susceptible chickens - (Abstract Only)

Luo, J., Mitra, A., Tian, F., Zhang, H., Chang, S., Cui, K., Zhao, K., Krause, M., Cheng, H.H., Song, J. 2011. Genome-wide histone modification profile induced by MDV in MD-resistant and -susceptible chickens. Plant and Animal Genome XIX Conference, January 15-19, 2011, San Diego, California. Paper No. 578.

Avian Disease and Oncology Laboratory (ADOL) research update - (Proceedings)

Fadly, A.M., Cheng, H.H., Dunn, J.R., Heidari, M., Hunt, H.D., Lee, L.F., Silva, R.F., Zhang, H. 2011. Avian Disease and Oncology Laboratory (ADOL) research update. Proceedings One Hundred and Fourteenth Annual Meeting of the United States Animal Health Association (USAHA), November 11-17, 2010, Minneapolis, Minnesota. p. 528-530.

Down-regulation of promoter methylation level of CD4 gene after MDV infection in MD-susceptible chicken line - (Peer Reviewed Journal)

Luo, J., Yu, Y., Zhang, H., Tian, F., Chang, S., Cheng, H.H., Song, J. 2011. Down-regulation of promoter methylation level of CD4 gene after MDV infection in MD-susceptible chicken line. BioMed Central (BMC) Proceedings. 5(Suppl 4):57. Available: http://www.biomedcentral.com/1753-6561/5/S4/S7

Low Dose Vaccination Revealed An Interaction Between Vaccine and Chicken Line Affecting Protective Efficacy - (Abstract Only)

Zhang, H., Chang, S., Dunn, J.R., Heidari, M., Lee, L.F. 2010. Low dose vaccination revealed an interaction between vaccine and chicken line affecting protective efficacy [abstract]. In: 5th International Workshop on the Molecular Pathogenesis of Marek's Disease Virus and 1st Symposium on Avian Herpesviruses, October 17-20, 2010, Athens, Georgia, p. 129.

Comparative Global Gene Expression Profiling Between rMd5- and rMd5deltaMeq-Infected Chickens: Host-Pathogen Interaction - (Abstract Only)

Heidari, M., Xu, M., Zhang, H., Lee, L.F., Silva, R.F. 2010. Comparative global gene expression profiling between rMd5- and rMd5deltaMeq-infected chickens: host-pathogen interaction [abstract]. In: 5th International Workshop on the Molecular Pathogenesis of Marek's Disease Virus and 1st Symposium on Avian Herpesviruses, October 17-20, 2010, Athens, Georgia, p. 91.

Meq is An Immunosuppressive Oncogene - (Abstract Only)

Heidari, M., Xu, M., Zhang, H., Lee, L.F., Silva, R.F. 2010. Meq is an immunosuppressive oncogene [abstract]. In:35th Annual International Herpesvirus Workshop, July 24-29, 2010, Salt Lake City, Utah. Paper #8.52.

Genetics and Vaccine Efficacy: Host Genetic Variation Affecting Marek's Disease Vaccine Efficacy in White Leghorn Chickens - (Peer Reviewed Journal)

Chang, S., Dunn, J.R., Heidari, M., Lee, L.F., Song, J., Ernst, C.W., Ding, Z., Bacon, L.D., Zhang, H. 2010. Genetics and Vaccine Efficacy: Host Genetic Variation Affecting Marek's Disease Vaccine Efficacy in White Leghorn Chickens. Poultry Science. 89(10):2083-2091.

Genome-wide Copy Number Variation and Temporal Genes Expression Analysis in Marek's Disease-Resistant or -Susceptible Inbred Lines of Chickens - (Abstract Only)

Yu, Y., Mitra, A., Luo, J., Tian, F., Zhang, H., Yuan, P., Chang, S., Liu, G., Xie, X., Song, J. 2010. Genome-wide copy number variation and temporal genes expression analysis in Marek's disease-resistant or -susceptible inbred lines of chickens [abstract]. In: 32nd Conference of the International Society for Animal Genetics Program and Abstract Book, July 26-30, 2010, Edinburgh, Scotland. Paper No. 2019.

Genome-Wide SNP Association Analysis for Loci Conferring Marek's Disease - (Abstract Only)

Chang, S., Dunn, J.R., Heidari, M., Mitra, A., Song, J., Zhang, H. 2010. Genome-wide SNP association analysis for loci conferring Marek's disease [abstract]. In: 32nd Conference of the International Society for Animal Genetics Program and Abstract Book, July 26-30, 2010, Edinburgh, Scotland. Page No. 5088.

Comparative Evaluation of Vaccine Efficacy of Recombinant Marek's Disease Virus Vaccine Lacking Meq Oncogene in Commercial Chickens - (Peer Reviewed Journal)

Lee, L.F., Kreager, K.S., Arango, J., Paraguassu, A., Beckman, B., Zhang, H., Fadly, A.M., Lupiani, B., Reddy, S.M. 2010. Comparative Evaluation of Vaccine Efficacy of Recombinant Marek's Disease Virus Vaccine Lacking Meq Oncogene in Commercial Chickens. Vaccine. 28(5):1294-1299.

Alternative Splicing Variants and DNA Methylation Status of BDNF in Inbred Chicken Lines - (Peer Reviewed Journal)

Yu, Y., Zhang, H.M., Byerly, M.S., Bacon, L.D., Porter, T.E., Liu, G.E., Song, J. 2009. Alternative Splicing Variants and DNA Methylation Status of BDNF in Inbred Chicken Lines. Brain Research. 1269(7):1-10.

Non-MHC genomic variation affecting Marek’s disease resistance and vaccine protective efficiency - (Abstract Only)

Chang, S., Dunn, J.R., Heidari, M., Lee, L.F., Song, J., Dodgson, J., Ding, Z., Zhang, H. 2009. Non-MHC Genomic Variation Affecting Marek’s Disease Resistance and Vaccine Protective Efficiency [abstract]. International Plant and Animal Genome XVII Conference, January 9-14, 2009, San Diego, California. p. 526.

Genome-wide assessment of worldwide chicken SNP genetic diversity indicates significant absence of rare alleles in commercial breeds - (Peer Reviewed Journal)

Muir, W.M., Wong, G., Zhang, Y., Wang, J., Groenen, M., Crooijmans, R., Megens, H., Zhang, H., Okimoto, R., Vereijken, A., Jungerius, A., Albers, G., Taylor Lawley, C., Delany, M.E., Maceachern, S.A., Cheng, H.H. 2008. Genome-Wide Assessment of Worldwide Chicken SNP Genetic Diversity Indicates Significant Absence of Rare Alleles in Commercial Breeds. Proceedings of the National Academy of Sciences. 105(45):17312-17317.

Transcriptional profiling of candidate genes induced by Marek's disease virus during cytolytic and latency infections - (Abstract Only)

Lee, L.F., Chang, S., Zhang, H., Heidari, M. 2008. Transcriptional profiling of candidate genes induced by Marek's disease virus during cytolytic and latency infections. American Veterinary Medical Association Convention Notes. 145th AVMA Annual Convention, July 19-22, 2008, New Orleans, LA. 2008 CD-ROM.

An integrated epigenetic and genetic analysis of DNA methyltransferase genes (DNMTs) in tumor resistant and susceptible chicken lines - (Peer Reviewed Journal)

Yu, Y., Zhang, H., Tian, F., Zhang, W., Fang, H., Song, J. 2008. An Integrated Epigenetic and Genetic Analysis of DNA Methyltransferase Genes (DNMTs) in Tumor Resistant and Susceptible Chicken Lines. PLoS One. 3(7):1-13.

Inhibition of Marek's disease virus replication by retroviral vector-based RNA interference - (Peer Reviewed Journal)

Chen, M., Payne, W.S., Hunt, H.D., Zhang, H., Holmen, S.L., Dodgson, J.B. 2008. Inhibition of Marek's disease virus replication by retroviral vector-based RNA interference. Virology. 377:265-272.

Survey of endogenous virus and TVB* receptor status of commercial chicken stocks supplying specific-pathogen-free eggs - (Peer Reviewed Journal)

Hunt, Henry D., Fadly, Aly M., Silva, Robert F., Zhang, Huanmin. 2008. Survey of Endogenous Virus and TVB* Receptor Status of Commercial Chicken Stocks Supplying Specific-Pathogen-Free Eggs. Avian Diseases. 52(3):433-440.

Development of an endogenous virus-free line of chickens susceptible to all subgroups of avian leukosis virus - (Peer Reviewed Journal)

Zhang, H., Bacon, L.D., Fadly, A.M. 2008. Development of an Endogenous Virus-Free Line of Chickens Susceptible to All Subgroups of Avian Leukosis Virus. Avian Diseases. 52(3):412-418.

Quantitative evaluation of DNA methylation patterns for ALVEs and TVB genes in a neoplastic disease susceptible and resistant chicken model - (Peer Reviewed Journal)

Yul, Y., Zhang, H.M., Tian, F., Bacon, L.D., Zhang, Y., Zhang, W., Song, J. 2008. Quantitative evaluation of DNA methylation patterns for ALVEs and TVB genes in a neoplastic disease susceptible and resistant chicken model. PLoS One. 3(3):e1731.

Marek's disease virus induces Th-2 activity during cytolytic infection - (Peer Reviewed Journal)

Heidari, M., Zhang, H.M., Sharif, S. 2008. Marek's disease virus induces Th-2 activity during cytolytic infection. Viral Immunology. 21(2):203-213.

Review of the initial validation and characterization of a 3K chicken SNP array - (Peer Reviewed Journal)

Muir, W.M., Wong, G.K., Zhang, Y., Wang, J., Groenen, M.A., Crooijmans, R.P., Megens, H.J., Zhang, H.M., McKay, J.C., McLeod, S., Okimoto, R., Fulton, J.E., Settar, P., O'Sullivan, N.P., Vereijken, A., Jungerius-Rattink, A., Albers, G.A., Lawley, C.T., Delany, M.E., Cheng, H.H. 2008. Review of the initial validation and characterization of a 3K chicken SNP array. World Poultry Science Journal. 64:219-225.

Polymorphisms of the bovine DAZL gene are associated with male fertility - (Abstract Only)

Liu, W., Wang, A., Zhang, H. 2008. Polymorphisms of the bovine DAZL gene are associated with male fertility [abstract]. Plant and Animal Genome Conference. p. 162.

Genetic bases for Marek's disease resistance - (Abstract Only)

Zhang, H., Heidari, M., Dunn, J.R., Yu, Y., Song, J. 2008. Genetic bases for Marek's disease resistance. Plant and Animal Genome Conference Proceedings. p. 96.

DNA methylation variations of TVB in ALV-resistant and -susceptible chickens - (Abstract Only)

Yu, Y., Zhang, H., Tian, F., Bacon, L.D., Song, J. 2008. Dna methylation variations of tvb in alv-resistant and -susceptible chickens [abstract]. Plant and Animal Genome Conference. p. 96.

Inhibition of avian tumor viruses by vector-based RNA interference - (Abstract Only)

Chen, M., Payne, W.S., Hunt, H.D., Zhang, H., Holmen, S.L., Dodgson, J.B. 2008. Inhibition of avian tumor viruses by vector-based RNA interference [abstract]. Plant and Animal Genome Conference. p. 257.

Genetic variation at the tumour virus B locus in commercial and laboratory chicken populations assessed by a medium-throughput or a high-throughput assay - (Peer Reviewed Journal)

Zhang, H.M., Bacon, L.D., Heidari, M., Muir, W.M., Groenen, M.A.M., Zhang, Y., Wong, G.K.S., Fulton, J.E., O'Sullivan, N.P., Albers, G.A.A., Vereijken, A.L.J., Rattink, A.P., Okimoto, R., McKay, J.C., McLeod, S., Cheng, H.H. 2007. Genetic variation at the tumour virus B locus in commercial and laboratory chicken populations assessed by a medium-throughput or a high-throughput assay. Avian Pathology. p. 283-291.

Characterization of LORF11, a unique gene common to the three Marek's disease virus serotypes - (Peer Reviewed Journal)

Lee, L.F., Silva, R.F., Cui, X., Zhang, H., Heidari, M., Reddy, S. 2007. Characterization of LORF11, a unique gene common to the three Marek's disease virus serotypes. Avian Diseases. 51:851-857.

Inhibition of avian leukosis virus replication by vector-based RNA interference - (Peer Reviewed Journal)

Chen, M., Granger, A.J., VanBrocklin, M.W., Payne, W.S., Hunt, H.D., Zhang, H.M., Dodgson, J.B., Holmen, S.L. 2007. Inhibition of avian leukosis virus replication by vector-based RNA interference. Virology. 365:464-472.

MDV-induced skin leukosis in scaleless chickens: tumor development in the absence of feather follicles - (Peer Reviewed Journal)

Heidari, M., Fitzgerald, S.D., Zhang, H.M., Silva, R.F., Lee, L.F., Dunn, J.R. 2007. MDV-induced skin leukosis in scaleless chickens: tumor development in the absence of feather follicles. Avian Diseases. 51(3):713-718.

Identification of a new splice variant of BDNF in chicken - (Abstract Only)

Yu, Y., Zhang, H.M., Bacon, L.D., Song, J. 2007. Identification of a new splice variant of BDNF in chicken [abstract]. Plant and Animal Genome VX Conference Abstracts. Paper #814. p. 305.

Putative evidence that genes outside the MHC have a significant influence on efficacy of Marek's disease vaccine - (Abstract Only)

Zhang, H.M., Dunn, J.R., Witter, R.L., Heidari, M., Bacon, L.D., Cui, Y., Song, J., Cheng, H.H. 2007. Putative evidence that genes outside the MHC have a significant influence on efficacy of Marek's disease vaccine [abstract]. Plant and Animal Genome VX Conference Abstracts. Paper #107. p. 128.

EXPLORING RPE AS A SOURCE OF PHOTORECEPTORS: DIFFERENTIATION AND INTEGRATION OF TRANSDIFFERENTIATING CELLS GRAFTED INTO EMBRYONIC CHICK EYES - (Peer Reviewed Journal)

Liang, L., Yan, R., Ma, W., Zhang, H., Wang, S. 2006. Exploring RPE as a source of photoreceptors: differentiation and integration of transdifferentiating cells grafted into embryonic chick eyes. Investigative Ophthalmology and Visual Science. 47(11):5066-5076.

THE THRESHOLD OF GENETIC SUSCEPTIBILITY TO MAREK'S DISEASE - (Abstract Only)

Zhang, H.M., Dunn, J.R., Heidari, M., Witter, R.L., Kulkarni, G., Bacon, L.D. 2006. The threshold of genetic susceptibility to Marek's disease [abstract]. 4th International Workshop on Molecular Pathogenesis of Marek's Disease Virus. p. 33.

GLOBAL GENE EXPRESSION PROFILING DURING CYTOLYTIC INFECTION OF MAREK'S DISEASE VIRUS: ARRAY ANALYSIS OF HOST-PATHOGEN INTERACTIONS - (Abstract Only)

Heidari, M., Huebner, M., Zhang, H.M., Silva, R.F., Spatz, S.J., Kireev, D. 2006. Global gene expression profiling during cytolytic infection of Marek's disease virus: array analysis of host-pathogen interactions [abstract]. 4th International Workshop on Molecular Pathogenesis of Marek's Disease Virus. p. 8.

Effect of selection for resistance and susceptibility to viral diseases on concentrations of dopamine and immunological parameters in six-week-old chickens - (Peer Reviewed Journal)

Dennis, R., Zhang, H.M., Cheng, H.W. 2006. Effect of selection for resistance and susceptibility to viral diseases on concentrations of dopamine and immunological parameters in six-week-old chickens. Poultry Science. 85:2135-2140.

SKIN LEUKOSIS INDUCED BY MDV - (Abstract Only)

Heidari, M., Fitzgerald, S.D., Silva, R.F., Zhang, H.M. 2006. Skin leukosis induced by MDV [abstract]. American Association of Avian Pathologists and American Veterinary Medical Association Scientific Program. p. 176.

Exploring RPE as a source of photoreceptors: assessing cellular differentiation in vivo - (Abstract Only)

Liang, L., Zhang, H., Wang, S. 2006. Exploring RPE as a source of photoreceptors: assessing cellular differentiation in vivo [abstract]. Association for Investigative Opthalmology and Visual Science. E-abstract 5541.

LYMPHOID ORGAN SIZE VARIES AMONG INBRED LINES 63, 72 AND THEIR THIRTEEN RECOMBINANT CONGENIC STRAINS OF CHICKENS WITH THE SAME MHC - (Peer Reviewed Journal)

Zhang, H.M., Hunt, H.D., Kulkarni, G.B., Palmquist, D.E., Bacon, L.D. 2006. Lymphoid organ size varies among inbred lines 63, 72 and their thirteen recombinant congenic strains of chickens with the same major histocompatibility complex. Poultry Science. 85:844-853.

PRELIMINARY RESULTS ON THE VALIDATION AND APPLICATION OF 3,072 CHICKEN SNPS BY GENOTYPING 2,576 COMMERCIAL AND EXPERIMENTAL BIRDS - (Abstract Only)

Cheng, H.H., Zhang, H.M., Muir, W.M., Groenen, M.A., Wong, G.K. 2006. Preliminary results on the validation and application of 3,072 chicken SNPs by genotyping 2,576 commercial and experimental birds [abstract]. Plant and Animal Genome XIV. p. 143.

DEVELOPMENT AND VALIDATION OF A PCR-RFLP ASSAY TO EVALUATE TVB HAPLOTYPES CODING RECEPTORS FOR SUBGROUP B AND E AVIAN LEUKOSIS VIRUSES IN WHITE LEGHORNS - (Peer Reviewed Journal)

Zhang, H.M., Bacon, L.D., Cheng, H.H., Hunt, H.D. 2005. Development and validation of a PCR-RFLP assay to evaluate TVB haplotypes coding receptors for subgroup B and subgroup E avian leukosis viruses in White Leghorns. Avian Pathology. 34(4):324-331.

IDENTIFICATION AND EVALUATION OF SNPS AT THE 3' END OF THE TVA GENE SEGREGATING AMONG ALSV RESISTANCE AND SUSCEPTIBLE LINES OF CHICKENS - (Abstract Only)

Zhang, H.M., Hunt, H.D., Cheng, H.H., Dodgson, J.B., Romanov, M., Bacon, L.D. 2005. Identification and evaluation of SNPs at the 3' end of the tva gene segregating among ALSV resistance and susceptible lines of chickens [abstract]. Plant & Animal Genome XIII Conference. p. 197:123.

RETROSPECTIVE EVIDENCE THAT THE MHC (B HAPLOTYPE) OF CHICKENS INFLUENCES GENETIC RESISTANCE TO ATTENUATED INFECTIOUS BRONCHITIS VACCINE STRAINS IN CHICKENS - (Peer Reviewed Journal)

Bacon, L.D., Hunter, D.B., Zhang, H.M., Brand, K., Etches, R. 2004. Retrospective evidence that the MHC (B haplotype) of chickens influences genetic resistance to attenuated infectious bronchitis vaccine strains in chickens. Avian Pathology. 33(6):605-609.

BEHAVIORAL AND PHYSIOLOGICAL FEATURES OF CHICKENS DIVERSELY SELECTED FOR RESISTANCE TO AVIAN DISEASE. 1. SELECTED INBRED LINES DIFFER FOR BEHAVIORAL AND PHYSICAL RESPONSES TO SOCIAL STRESS - (Peer Reviewed Journal)

Dennis, R., Zhang, H., Bacon, L.D., Esteves, I., Cheng, H. 2004. Behavioral and physiological features of chickens diversely selected for resistance to avian disease. 1. Selected inbred lines differ for behavioral and physical responses to social stress. Poultry Science. 83(9):1489.

EVALUATION OF AVIAN LEUKOSIS VIRUS SUBGROUP A (ALVA) AND SUBGROUP B (ALVB) RECEPTOR GENES IN RECOMBINANT CONGENIC STRAINS OF CHICKENS - (Abstract Only)

Zhang, H., Bacon, L.D. 2004. Evaluation of avian leukosis virus subgroup A (ALVA) and subgroup B (ALVB) receptor genes in recombinant congenic strains of chickens [abstract]. International Conference on Animal Genetics. p. 115.

OVIDUCTAL PROLAPSE LED TO MORE THAN ELEVEN PERCENT OF HENS DEAD IN A HIGHLY INBRED LINE OF WHITE LEGHORN CHICKENS - (Abstract Only)

Zhang, H., Pandiri, A.R., Kulkarni, G. 2004. Oviductal prolapse led to more than eleven percent of hens dead in a highly inbred line of white leghorn chickens [abstract]. International Conference on Production Diseases in Farm Animals. p. 108.

CHICKEN TUBBY-LIKE PROTEIN 1 (TULP1) GENE MAPS TO CHROMOSOME 26 - (Peer Reviewed Journal)

Zhang, H.M., Cheng, H.H. 2004. Chicken tubby-like protein 1 (tulp1) gene maps to chromosome 26. Animal Genetics. 35:165-166.

SNP IDENTIFICATION AND GENETIC MAPPING OF CHICKEN EPHRIN TYPE-B RECEPTOR 2 GENE TO LINKAGE GROUP E54 - (Peer Reviewed Journal)

Zhang, H.M., Cheng, H.H. 2004. SNP identification and genetic mapping of chicken ephrin type-B receptor 2 gene to linkage group E54. Animal Genetics. 35:162-163.

THE EFFICACY OF RECOMBINANT FOWLPOX VACCINE PROTECTION AGAINST MAREK'S DISEASE: ITS DEPENDENCE ON CHICKEN LINE AND B HAPLOTYPE - (Peer Reviewed Journal)

Lee, L.F., Bacon, L.D., Yoshida, S., Yanagida, N., Zhang, H., Witter, R.L. 2004. The efficacy of recombinant fowlpox vaccine protection against marek's disease: its dependence on chicken line and b haplotype. Avian Diseases. 48:129-137.

A PCR BASED SNP ANALYSIS OF THE CHICKEN TVB RECEPTOR GENE - (Abstract Only)

Zhang, H.M., Hunt, H.D., Cheng, H.H., Bacon, L.D. 2003. A PCR based SNP analysis of the chicken TVB receptor gene [abstract]. Poultry Science. 82(1):49.

RE-ESTABLISHMENT OF A TRANSGENIC CHICKEN LINE 0-ALV6 AT THE AVIAN DISEASE AND ONCOLOGY LABORATORY - (Abstract Only)

Zhang, H., Bacon, L.D., Kulkarni, G. 2003. Re-establishment of a transgenic chicken line 0-ALV6 at the Avian Disease and Oncology Laboratory [abstract]. Poultry Science Association. 82(1):49.

AUTOMATION OF KNOWLEDGE DISCOVERY PROCESSES IN BIOLOGY INFORMATICS - (Proceedings) - (23-Jun-03)