Project Number: 1235-51530-053-08
Project Type: Reimbursable

Start Date: Jul 22, 2011
End Date: Jul 21, 2016

Objective:
The objective of this agreement is to work together to conduct studies examining the effects of phytochemicals on cancer cells and cancer stem cells. Studies will focus on genes important in the process of carcinogenesis.

Approach:
ARS will use cell culture models of prostate cancer cells or prostate cancer stem cells to test the effects of diet-derived phytochemicals on their ability to inhibit carcinogenesis. The focus will be on cellular pathways that may be important in the carcinogenesis process, including steroid hormone-related pathways, xenobiotic metabolism, etc. Gene expression of marker genes for specific pathways will be monitored to assess biological efficacies of various diet-derived components. The Cooperator will provide funding for material and supplies for the experiments as well as funding for personnel. ARS will conduct experiments and provide mentoring of visiting scientists involved in the project.