ARS | Publication request: Dietary fiber is related to metabolic risk factors in the Framingham Offspring Cohort

Submitted to: Annual Scientific Meeting NAASO, The Obesity Society
Publication Type: Proceedings
Publication Acceptance Date: June 1, 2006
Publication Date: October 20, 2006
Citation: Mckeown, N., Meigs, J., Rogers, G., Saltzman, E., Liu, S., Jacques, P. 2006. Dietary fiber is related to metabolic risk factors in the Framingham Offspring Cohort. Annual Scientific Meeting NAASO, The Obesity Society. October 20-24, 2006: Boston, MA. Obesity. 14(9):A22.

Technical Abstract: Metabolic and epidemiological evidence suggests that high fiber diets improve glucose and lipid metabolism. We examined the association between energy-adjusted dietary fiber intake and several metabolic markers of disease risk in X men and Y women in the Framingham Offspring Cohort. Dietary fiber intake was inversely associated with fasting triglycerides (mean: 137 mg/dL in the lowest and 122 mg/dL in the highest quintile of intake; P for trend <0.001), fasting insulin (29.4 and 27.0 mu/mL, respectively; P for trend <0.001), 2 hour post challenge insulin (82 and 73 mu/mL, respectively; P for trend <0.01) concentrations and positvely associated with fasting HDL cholesterol (mean: 45 and 46 mg/dL, respectively; P for trend <0.05) after adjustment for sex, age (years), BMI, waist circumference, energy intake (kcal/d), multivitamin supplementation use (Y/N), alcohol intake (g/d), blood pressure medication (Y/N), current cigarette smoking (categorical), physical activity score (continuous), percentage intakes of SFA and PUFA,. Interactions significant for BMI - NEED TO DO. No associations were observed between dietary intake and waist circumference, systolic blood pressure, diastolic blood pressure, fasting glucose or 2 hours post challaenge glucose. These cross-sectional findings support the hypothesis that a high dietary fiber intake is favorably related to metabolic risk factors, and therefore, increased intake of dietary fiber may reduce CHD and type 2 diabetes mellitus risk. Although increased consumption of dietary fiber and grain products is widely recommended to maintain healthy body weight, little is known about the relation of whole grains to body weight and long-term weight changes.